The aim of the present study was to explore the relationship between personality traits, ACADEMIC stress, and ACADEMIC PERFORMANCE in college students. On a random sample of 419 students (166 male and 253 female), the short form of The Big Five Inventory and Student-Life Stress Inventory were applied. The relations between personality traits, ACADEMIC stress, and ACADEMIC PERFORMANCE were studied using correlation and hierarchical regression analysis. The results of pearson-product moment correlations showed that there was a significant positive correlation between conscientiousness, extraversion, and openness to experience, agreeableness and ACADEMIC PERFORMANCE and there was a significant negative correlation between neuroticism factor and ACADEMIC PERFORMANCE. A significant negative correlation was found between ACADEMIC stress and ACADEMIC PERFORMANCE. Also, the significant negative correlation was found between extraversion and conscientiousness and ACADEMIC stress and a significant positive correlation was found between neuroticism and ACADEMIC stress. Hierarchical regression indicated that personality traits accounted for variance in ACADEMIC stress: 5% by extraversion and 3% by neuroticism. Also, hierarchical regression analyses predicting ACADEMIC PERFORMANCE indicated that personality traits and ACADEMIC stress accounted for variance in ACADEMIC PERFORMANCE:12% by conscientiousness, 10%neuroticismand 6% ACADEMIC stress. The finding emphasise the need recognized the role of personality traits in ACADEMIC stress and the role of personality traits and ACADEMIC stress in ACADEMIC PERFORMANCE. Implications of these findings for improving ACADEMIC PERFORMANCE are discussed.